Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.

Belongs to the nucleoporin Nup133 family.

1142 amino acids

MFIVHRRFFQNEKAFTPAGKHEKVADGNKHETLATSEYPKVCASNDLYKILQISAPKVGNFTIHDAPVVGLIDSILEYYLYISVKVRKAWIAGYGSQPQNLICFDWERFTGILDQQSLNSPPLAGFVKPDPTSAEPGFLLLWPASGDLFYWERTSLMNVEVSAPEFPGFLHYRIQLKRYESCKNLVSAEPAGFFLTLSSGRLLHLNLKDSDGNSSIQVRILFPGLHIPNCLLSLYNSIFAFTSGRVIPIRCGSIKGPGERLVYSMHSGSTLRIWEIFGTGDHHLLRGFDIYDIILDSIQESFSYVNRFLILDFSVSTSDPYTLACLVSWRDNASLFNYAAIIISFNHQMIPHVSQFCHVRSYLSAILPSVCRIFLPSPGTVVFCVFDVTFAMFHKVRGKEGTFYVEENLVVNNLTSKSRVLDFGMEDAIYEKSTHTLLKTPALILLTEGHGIIRIESSASYLKTSFSATTYLRSRLSQFASQSPLFREQFLLNFDFTYNLSESEVYNTVFNLCDELYTTPCKKNMSVLETLHSQQRDLMEIVLVAFKYLHLSPSNRLQLWLKVAYCSALADLYELLMCNEKMSNLLRRVLKIMSSNDNIDELFLKKCLNINLLLQHLSSEYSQISGQDASNAQKRIEVIVNVNNVYGTIFGNELAYRQEKISKFTDPSSVIRSDLWTVEVDHLDLLRKQIEDSISLHRDVRDSKDAHILKVSNKLRKQILHLVEQNCLLIFDLHNGTDDTIVKSHNFQKFEEEFGNSRKEWLQYLASVGYLEKAIDLAEKVKDFQTMVILLDCLDPKDPTIKLQKQKACLNKYKEEFADVIFFYLVDTEQYASLLHDFLEYQSLLISFFEANDLLNLLWIFEAQNGNYGRASEILFRDCEPEENRIIGKISQLALAKLYSWTNRIEGENIILSNETEVIENHLAILLIQEQYAEMLSSLVDITEDEGEAVEAIVTSNCVNLSENSIRAWLVSSAVERLIQNEYTTLCEMVDFFSSFSLRECSFKEVDLALELLERATITKDVYFYLKDLVYRRFLLQVNWAEIIDAHEDLESSFFPMVKEIMLESDFLIWLQHMEHNIHDESKHYLKSEKNFLQSVYSSLSESQVEDYQMELFREKQIFSVLCKDRELYILIPKLLDVATKQ

131.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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