Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-1 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp-2 and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).

Belongs to the NCBP1 family.

798 amino acids

MSRRRQFDDEDEVQMKRRRGAPLIEDVEKKLQGVIGKVGENTGSSIECNLDKLTAFLHDDLEKYRASIIDIIAGCAIYLPNRVTVYTTLVGLLNSKNFNFGGDVVEKLISEQQDLLSKQKYQEAQNLAIFLCDLGNSGVLTAQSIGEYLESFIAAAFEENMPQVRNDYYIQTVLRCLPWIGKELTEKAPEQMENIGEAIGKYLELRNKNHVALLQVWREGSTDQKQEDYLESLSAQIEALRNADWVENHIPRHYSGFETTLQDALQHNLPSFQSPEHTSDMIYPYPLVVFRLFQDADCSAFSSKPLPGDSSIDRFLFEGEIAWIIEKNQFNRKACARELLAFAEENPSVPIGFLIFETIFGQMLRLPHAPYPAIFHCSLVLELLKLKPDDYPQILVQTVECIYRRADSMQPVCIDRMVDWFSFHLSNFQYRYTWTDWKDCLNKDAFSGSQIFVREVIEKCRRFGSYEKIIAALPQDFVKIHPCSPEVRYLIDEEDTALVQRAETFTQMFQERQPAEAFLNELKSNDENDELPYNINEFGLFVMVMLKMASKTYSHNFSALFRYQTTLKTVCDASELYQEKLLETLYSCWKTNQQMLMILTDKLLKMQVIDCSAVVGWLFDEKMWQEHDRQWLFEVLNQALEKLTRQINVVEKDIKELTEKTENKIKEEDDEESDIKMDEDETKEEKFKQDLEDLENNKEKLERMVTFQKGLFNDFLIAFIEEIKNAATSNTSEMDGSGDTPGTQTPKFMWLRGRFCHVLLAHAETLLKHSSNIADEVFSEGTDPSIIECFNQFQSLRL

92.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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