Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Essential for mesoderm formation and axial patterning during embryonic development. Activates the activin-like signaling pathway to induce dorsal and ventral mesoderm in animal cap ectoderm. In addition, also dorsalizes ventral marginal zone (VMZ) tissues during gastrulation. Induces muscle actin. Appears to act as both a short-range and long-range morphogen. The unprocessed protein inhibits bmp- and wnt-signaling.

Belongs to the TGF-beta family.

405 amino acids

MASLGVILFFVIASLIHGKPIHSERKAAKIPLEGSNLGYKKPNNIYGSRLSQGMRYPPSMMQLYQTLILGNDTDLSILEYPVLQESDAVLSLIAKSCVVVGNRWTLSFDMSSISSSNELKLAELRIRLPSFERSQDVTVEIYHTKEGQENLFMGSFKTNPSVAMGSSWKIFNLTRMLQYYLHQGEPFTNVEYIEVKNMHERAKPHVIKRGVRAEVEEGLQRNKDNTPASSFPTERVVLVVFTRDKPTASHFGSPSLIHTVESSKYVMSENTVRVTDTRRPRRNQKTKNTIVMNTIPSRSVGKTLCRRVDMIVDFEKIEWGDRIVYPKRFNAYRCEGACPIPLNETFKPTNHAYIKSLVKLYDQEKVECSSCVPVKMSPLSMLLYEDGEVVLKHHEDMIVDECGCN

46.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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