Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration (By similarity).

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.

336 amino acids

MGRGKKMSKPGDGRSGDVPDTGRTGGTNENHPKINGEVAHLGQPKIYSFMSPTKSPSARPPLQEENSVAHHESKCPGKPLTETRKKAEVEKKRISSGTELSVKPSEQRETECNSIGEFLDPKQEQTDVRRNIALPPADKLNHQKMVKDKPLRRKAQRKKSPNRKLTDYYPVRRSCRKSKTELESEEKKRIDELIQTGKEEGMKMDMITGKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREATYAQDSNTGCYMYYFQYLNKTYCIDATRETGRLGRLINHSKSGNCHTKLHNINNVPHLILVASRDINVGEELLYDYGDRRKSSLEAHPWLKN

38.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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