Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.

Belongs to the NAPRTase family.

589 amino acids

MSQSNTPLKRKKTENGYSENGSTTGATSNQIRELKRATTVDYVYRDQESKDKIKPLNGFVTPLLTDLYQITMAYSLWKNNRHEIPAVFDLYFRKSPFGGEFTVFAGLEEVIRFVSDFHYTKEEVGFIKEMIPDCEQEFLDYLSKLDSSSVTLYAMKEGSVVFPRVPLLRVEGPMILCQLFETTLLCLVNFASLVATNAARHRLAVGKEKVMLEFGLRRAQGPDGAMSASRYSYLGGADGTSNVLAHCFFGIPIRGTHAHSFITNYSGPDELLDASIKDTNGNVHNLLEMSQKYRDELGYTATNLSELVAFVAYARTFPNGLVALVDTYDTLASGVPNFICVALALHQLGYKAVGIRLDSGDLSYLSKASRKLFKQIGEQFKIDYFEKFSIVASNDLNEPTIIALNRQGHEIDVFAIGTNLVTCQAQPALGCVYKLVEINGSPRIKLSQEANKITLPGRKTAYRLFGSEGHPLVDLLVDDNDMIKDGSKQIPQVGKKVLCLHPFEEQKRVIVTPVQIEKLHHIVFEKGQLTMPLPALNDIREYCFQQISKVREDHLRNSNPTPYKVSVTKELFDTLHNLWLDSVPIKEMK

66.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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