Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (By similarity).

818 amino acids

MWKLQPTESGGESVILLAGQEYVVGRKNCEILLTNDQSISRVHAVLTVTEQAVTLKDSSKYGTFVNGEKLESGSTKTLQTGYKITFGVFQSKFSLEKECIVVCSSCVDNEGKVTLSQDIRSVGGRLVSSWTSDCTHLVMPTVKVTIKTICALLCCRPIVKPAFFSALSKAVQQKLPLPKAERFRPQIDEPSLARDDVDLSARPERKSLFKGKTFLFLSSKQMKRLSVAVSCGGGVSQLLDEGALPVSLLESSSTCVLDMISGNSQPVISPASKKWLDSVGQILHRKGLRFITESEVGLAAIHVSNQTYCNPCSSLQSESVKTNPVFASATLSQSTAVDETALAAPSQNITAYVVNTEISQDQSRMVTSGISAVGETPEKTNPTQKASTTNKPLSLGQEPSSTRIVQETVMSSESFSVVESEQKMKKGSVVSARGRVEGPVKQKAPSSGNTTLKHSPQKQTALTSFFQPSSKKRPRESSASSVQPEPKFFKKDIKDNEDDIQQSFSVNRSHKTSSEETSLGQACGTGQNSSSKKRKEPEQDTLLGAEEPTAADDLEMSLEELEFLMSDEMDEPPQTAANKKQRLESGLTSKINSEQLSNQQEVTESKGRKGEKNQQSSSSNIQSMQLDRAGPAVTNQDTQTQSKRSPPDLEAHSSANKGPSKNKTPELEEVKKEEVSFVVNSRPQNGISQTSEAVLKQEMQASTSNSGPKNDPDLPRKLLQVQFMSLTVNNSSRSRPGPLQTHNPNDKNVKRFRKKNVPGFDGLPKIIGGSDLVAHNRSKHSELEEWLRQAAEEEKLNEREETLGDDLFRYNPRPAKKR

89.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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