Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (By similarity). Binding of FMLP to the receptor causes activation of neutrophils (By similarity). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).

Belongs to the G-protein coupled receptor 1 family.

single

348 amino acids

NFSTPLNEHEEVSYESAGYTVLQILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLPLADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIIGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERKNVAITMLTARGIIRFVIGFSMPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLSTVWLKEMLFYGKYKIINILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIRSLPTSLERALSEDSAPTNDTAAKCASPPAETELQAM

38.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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