Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping (PubMed:15020415, PubMed:8601480). Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity (PubMed:8462849, PubMed:9789046, PubMed:15141086, PubMed:28853436).
Family
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
Species
Caenorhabditis elegans
Sequence
MTLKIAFFTLILLVSIERVYSSDEEYRLLKDLREGYDPVERPVADHRKPVNVKLRLILQQLVDVDERNQVITLVVWNQYTWNDYKLRWSPEEYGNITTLQIPHGTLWKPDILLFNSANEHFDASFPVHMVVSSNGDVLFAPPGIVSFSCSLSMTWFPYDQQVCYLKFGSWTYGKKLDLQIDDSDLPDGHKMDLQYYIPNGEFDLLATPAFRKSTTFLDETYVELYFHMHLKRRTMYYGLNWIVPSILISLSNILGFTMPPECGEKITLQITNFLSVMVFLAMVSEVAPPTSESIPIIAAFFSLSIVILGLSICASLIIVNIFFRHPKTHRMGDWTRYVFLEWLPWFLLMSRPEHTFCRPRREEEKNDEEAGGDGTKLLENQQHQPRPRLLVNSQLVMDSTVPYLEEIIGYLKVFKAKLDDDEEEEEEILNWRFMAMVIDRLSLFLFTGLIFGTTALIFAFCPNLFTDSPIVDIE
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
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Protein synthesis service