Acts as a neurotrophic factor in postnatal mature neurons, enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance.

Belongs to the cytochrome b5 family. MAPR subfamily.

169 amino acids

MAGPAPGRRLVALALIVALAVGLPTAGAGQAPRPAERGPPVRLFTEEELARYGGEEEDQPIYMAVKGVVFDVTSGKEFYGRGAPYNALTGKDSTRGVAKMSLDPADLTHDTTGLTAEELESLDDVFTRVYKAKYPIVGYTARRILNEDGSPNLDFKPEDQPHFDIKDEF

18.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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