Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.

Belongs to the acetyltransferase family. ECO subfamily.

843 amino acids

MSIQEKSKENSSIVTKESEDENLEEEVESSQNSPTKKSGSKEAVKTPVRFSNKSKTNESEFGMRMSTRSASCSADKTATNSFNKNTVTLKGQSQESSKTKKLCQEKLSLGILKGNEQLHRRSQRLQQLTECTTRSLRSREIHGQIQTVKQNQQSARREQCNSTQSKCNKVKVNQKHVKRKVLEIKSDCKEDRHSVTNEVINSPKGKKRKVQHQTTSTCSSQCNQGSEKCLQKTSRKEEIKPVPVTADIRKLKAATSVVSKKNELRKSAHTQVSTSTKRPQIPLPLVPEHSDDQELEQAGKSKRGSILQLCEEIAGEIESDTVEVKKESSCVESVKEEKPAEVKLQGTDAERQILHHKEANQDVRSNRFFPSRKTKPVKCVLNGINSSTKKNSNWTKIKLSKFNSVQQHKLDSQVSPKLNLLQTGLSTSVLEMPHPVSQSTFLEMKAHGNVTCQRDKMKGIKSEEVKINNIAIEINKATKRDPGNCNLDNHIKPSPDSSLDNQMKLSCESAPDQNFSICSASEVETNPLENTAAASTLLSQAKIDEDRTFPGSAPNQQHSVLSDEASINRKNRDVPPNHSQLKHDSHLEITIPKSLKLKDSEKVDEKQLVIDAGHKRFGAVSCNICGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNTT

95 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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