Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses.

Belongs to the NanM family.

384 amino acids

MNMKTLLTYATLLSVTAFSHVVYADNQWPDLPTGFKDGVGAQVGSKVYVGLGSLGKSFYVLDLNALSKGWQKIADFTGAERSGATASVIGNYIYLFGGSGKAEPSDPSPILFDSVYRYDTKKDSWEKMNTTSPVGLLGASSYSPDNRQILFFGGYNKAYFDRYLRDISTTDKQVNPEVWQRIVDDYMGMTPTDYKWNRNVISYLPEKQEWRDLGVSTYLPNCGSATVIEGNKVTLISGEIKPGLRTAEVKQYEFGMDQPWKSLLPLPAPQTSNIQEGVAGAFSGKTNGVVVVAGGANFHGAKQAFENGKMFAHEGLPKAFNSEIYVEKEGIWSTVNSLPEGLAYGASFTTSEGVLIVGGEKSGKEMSHKVYMLAWNGSTVEVID

41.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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