Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.

Belongs to the stealth family.

1219 amino acids

MLVVNSLLKLLQRQTYTCLSHRYGLYLCFGGLVLMIVSAFQFGEVVVEWSRDQYHVLFDSYRDNVAGKSFQTRLCLPMPIDVVYTWVNGTDINLLKDLRAVRQRLEEEQKALRERLGKNGSEITEAPKGRPECLLSHCIMGPVLVLDPALPANITVKELPTLSAAFSSAKELLQVAKPLHPSSSVTALLFHSHTEAEKAHADALKDLLTHSISRGYLTTDKEAPGLVRMHTLAYLSGFPASLKETEQLRVKLPAVVTSKTKKLQLYSEASIALLHLNTAQDFTDLTQQAKKNLTLDGKELTVSSAFLFWDLTAISQSKQDEDVSASRFEDNEELRYSLRSIEKHAPWVRHIFIVTNGQIPSWLNLDNPRVSVVTHQDIFQNQTHLPTFSSPAIETHIHRIPGLSQKFIYLNDDVMFGKDVWPDDFYSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCQGSSRFGGAGGSVIGGGQPWQFAGGLGGLAGMSFCNQGCANSWLADKFCDQACNVLACGFDVGDCGQDNLNQLHRIVLRRNQTLYTLPQGELRPYFSFSGLANRVSEAHVADNQVLRHTSVANKWKTIHLLLLPGHNATQIHYNITFQSTDHHDFIMTFSVSVDTRELPKSNTSTPVRDKEEEPKPTVATPEPEVPFEAVPKEKQGPKVREQTHGDVQVPVLNETLLPDEVKIELKKLNEKLMSGDITIKGFNLTKAMLLEPYKEKDQFTLKHEKDKEEKQKLSPVAQLQNERAAARVKREKGENVDQLKPVAPSLVPVQIDDVTTKAQSRLFNIEKPHMFHLLSNLKGNLSKERDSDSEGHLRERPTGRRLQFYSDSLNRGFLPWEKRKFFQDLMEEVNRLQTELQYTADRTATGRRLQDTFADSLRYVNRLLNAQFGFTSRKVPAHMPHMIDRLIMQELQDTFPQEFDKTSSHRVRHSEDMQFAFSYFYFLMSAVQQLNISEVFDEIDTDHSGVLSDREIRTLATRIHELPLSLQDLTSLEQMLINCSKSLPSNLTHLHAVSPTQEAYYDPSMPPVTKGLVIHCKPITERIHKAFKDQNKYKFEIMGEEEIAFKMIRTNVSHVVGQLDDIRKNPRKFICLNDNIDHIHKDAGTVKAVLRDFYESMFPLPSQFELPREYRNRFLHMTELQEWRIYRDKLKFWTHCVLVTLVVFTVMSFFAEQLVMLKRWLFPRRRVSKDANPERV

139 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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