Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.

Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.

657 amino acids

MRLKIGFILRSLLVVGSFLGLVVLWSSLSSRPDDPSPLSRMREDRDVNNPLPNRGGNGLAPGDDRFKPVVPWPHVEGVEVDLESIRRKNKAKNEQERHAGGDSQKDIMQRQYLTFKPQTFTYRDPVLRPGVLGNFEPKEPEPHGVVGGPGENAKPLVLGPEYKQAAQASIKEFGFNMAASDMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLTEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPIIDVINGNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPREKRLRKTKTEPYRSPAMAGGLFAIERDFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGNPPPLYVGSSPTLKNYVRVVEVWWDEYKDYFYASRPESKALPYGDISELKKFREDHNCKSFKWFMEEIAYDITAHYPLPPRNVEWGEIRGLETAYCIDSMGKTNGGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGPDGSKVMITHCNLNEFKEWQYFKNLHRFTHIASGKCLDRSEVLHQVFISSCDNGKMTQKWEMNNIHSV

75.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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