Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as the pcu1, pcu2 and pcu4 cullins and other proteins.

Belongs to the peptidase C48 family.

420 amino acids

MSSSPTVLELFDVCFKQEDVDSLKKPNWFTDVSIDYVDELIEHLWFPSYPNQANEILLLRPSLVFLLAEAAISPEELKVALPKKLMNCKYLFMPINDLDKHAAGSGGSHWSLMVASIPDGQCYYYDSLSNGKTKDCRSALARVSDLFKKKFTIECMPVQQQRNGYDCGAHVCAFTLELVRRLLHSPMPTSSMWNLSTFQPDVTAIREQLSRCLDHIINSLGTRVSGDFDEDFPTGTVFFDLESHLPLLDVALPVLPKSSDSSETSHESSNSNLKKSSESGSTNHHNNHESDKDLHHEGHHHHHHHHHHHHSHDDDPSSPAEKKQNHVPSPSEKIQDHVPSPSEKKQDRVPSPSNNKEDHLPLLSDEKLDKSAIDKIEPTPLPSVHMNSHIAKGELPKFHNSTDNPFLTPPEELVSGDFPF

47.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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