Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex ube1c/uba3-ula1 and linkage to the E2 enzyme ube2m/ubc12. Attachment of nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).

Belongs to the ubiquitin family.

77 amino acids

MLIKVKTLTGKEIEIDIDPTDKIQRIKERVEEKEGIPPSQQRLIFGGKQMGDDKPASEYSIEGGSVLHLVLALRGGL

8.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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