NADP-dependent oxidoreductase; part of the lna gene cluster that mediates the biosynthesis of diastereomeric piperazines. Lna and lnb clusters encode sets of enzymes that produce overlapping sets of previously undescribed metabolites such as piperazinomycin-like metabolites or morpholine (PubMed:23281040). The lna and lnb biosynthetic pathways appear to be part of a signaling network that controls the formation of sclerotia, a resilient overwintering structure (PubMed:23281040). One primary function of the non-canonical nonribosomal peptide synthetases lnaA and lnbA consists in the reduction of L-tyrosine (PubMed:23281040). The presence in the clusters of tailoring enzymes such as the oxidoreductases lnaB, lnbB, lnaE or lnbE, as well as of the cytochrome P450 monooxygenases lnaC, lnaD, or lnbC, might explain formation of various diastereomeric piperazines (PubMed:23281040).

Belongs to the NADP-dependent oxidoreductase L4BD family.

371 amino acids

MTRVTMDQDTENKVLVIKNMDSGYLVAGEQVTLEDVSYDATEPLAEDELMVQLLYATYDLFKRDLASSSADATELRGRKPVETMSIAQVIKSNNKQFQEGDMVIGRLPVQQYVLIKADDATELKLLENPCEFDDIRLFLSVLGVPGLLAFSSLYEIGRPKKGETILIAGASDEIGQLVGQMARLEGLKVFGSVESDEKLDFLITELGFDGGFNYAKESPYEALPRLVPNGIDIYYDNLSWMSRLNIGGLDTHFDLLGSRHLNAAFSSMRRYGRIMFYGTIAEQTVLDPIIGMFLHNTVLKRLTIRGFGLSDPSFGKKWGKLHMERMQQWVKEEKLKIPTFEITGMDNAAKAFVEAFYSSENTHTHTILAVT

41.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.

Make lnaE using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)

Order Here