NADPH-dependent pterin aldehyde reductase involved in pterin aldehyde salvage during folate turnover. Catalyzes the reduction of diverse aromatic and aliphatic aldehydes (e.g. acetaldehyde, n-propanal, 1-naphthaldehyde, benzaldehyde, cinnamaldehyde, n-butanal, n-hexanal, n-pentanal, 2-naphthaldehyde, n-octanal, n-nonanal and n-heptanal), in addition to the conversion of pterin-6-aldehyde (PtCHO) to 6-hydroxymethylpterin (PtCH(2)OH), and the conversion of dihydropterin-6-aldehyde (H(2)PtCHO) to 6-hydroxymethyldihydropterin (H(2)PtCH(2)OH) (PubMed:17550420). Cannot reduce the pterin ring (PubMed:17220358).

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

242 amino acids

MTMATPFSGAANSIVAARTVLITGVSKGLGRALALELAKRGHTVIGCARSQEKLTALQSELSSSTNHLLLTADVKSNSSVEEMAHTIVEKKGVPDIIVNNAGTINKNSKIWEVSAEDFDNVMDTNVKGVANVLRHFIPLMLPRKQGIIVNMSSGWGRSGAALVAPYCASKWAIEGLSRAVAKEVVEGMAVVALNPGVINTELLTSCFGNSASLYQAPDAWAVKAATMILNLTAGDNGGSLTV

25.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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