NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

Belongs to the complex I subunit 1 family.

324 amino acids

MIGMALTAIISTMLIMVLLVVAGTFTWVERRVLGFVQERLGPNRVGPFGFLQWVADTVKILTKEDRPPPGADRVAYILAPMVAATPVLAGFGVVAFGDGLALANIDVGVMFLLGMMGLTVYGVVLGALASHSRFALMGGLRAAAQMLGYEAFLGLSLLGVVMIAGSLSLTEIVHAQRDVWFVLLQPFGAALFCIAGVAAAHRLPFDLPESENDLVAGYLTEYTGMSFGLFFLGEYLAVLLVASLAVTLFFGGWLGPVWLGPYLPGPIWFGLKVGVIALIFIWIRATLPRPRYDQLVRFAWKIALPLALANLLLTGLIVVARSAP

34.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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