NADH-cytochrome b5 reductase-like protein; part of the gene cluster that mediates the biosynthesis of asperlin, a polyketide showing anti-inflammatory, antitumor and antibiotic activities (PubMed:30339758). The first step of the asperlin biosynthesis is the production of the intermediate 2,4,6-octatrienoic acid by the highly redusing polyketide synthase alnA with cleavage of the PKS product by the esterase alnB (PubMed:30339758). 2,4,6-octatrienoic acid is further converted to asperlin via several steps involving the remaining enzymes from the cluster (PubMed:30339758).

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

452 amino acids

MASPASITLAEVARHSSPNDLWIVIEGNVYDVAEYREDHPGGDEILRQFAGKDATTEFQDAGHSNDAYVKLKTLLVGSLQSKTLPENQPEESSRIVSIAVSDRGKIPTKRQARNGNDTSKYGQLPSLVLAGGLALLFFTLKQHPWQSIQGYLSQAQVSRVQSSGWVGFLGGFLTATTLNTAAATFVGLTAKKTLLLRHRELEEYPRVKQHYLPLPPKKPGISGENTQQFLTLVDRQCIAPNVYKVRLQGDGLVIGLGQHLKVLAEIDGRKIQRSYTPVSPVGNSPKVDLIIKVYPKGQLGNYLLNLPLQSRVEIRGPFGRYSPSPTWKHIACIAGGTGIAPIYQVMRAWPGEITLLYGNETWEDILLREELEQLVLQSPRRIKVHHVLGQPKSDWKGLRGWITREMIQDLLPEPSSSTGFLVCGPDGMVRAIRGHFEAIDANGEEKANVFVF

50 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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