Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized (By similarity).

Belongs to the complex I 75 kDa subunit family.

748 amino acids

MGLGILASRTIRPASRLLQSQTSNFFLRTIVSKPELQSPESAAVSEPEPPTQILPPRNPVGGARVHFSNPEDAIEVFVDGYAVKVPKGFTVLQACEVAGVDIPRFCYHSRLSIAGNCRMCLVEVEKSPKPVASCAMPALPGMKIKTDTPIAKKAREGVMEFLLMNHPLDCPICDQGGECDLQDQSMAFGSDRGRFTEMKRSVVDKNLGPLVKTVMTRCIQCTRCVRFASEVAGVQDLGILGRGSGEEIGTYVEKLMTSELSGNVIDICPVGALTSKPFAFKARNWELKATETIDVSDAVGSNIRVDSRGPEVMRIIPRLNEDINEEWISDKTRFCYDGLKRQRLSDPMIRDSDGRFKAVSWRDALAVVGDIIHQVKPDEIVGVAGQLSDAESMMVLKDFVNRMGSDNVWCEGTAAGVDADLRYSYLMNTSISGLENADLFLLIGTQPRVEAAMVNARICKTVRASNAKVGYVGPPAEFNYDCKHLGTGPDTLKEIAEGRHPFCTALKNAKNPAIIVGAGLFNRTDKNAILSSVESIAQANNVVRPDWNGLNFLLQYAAQAAALDLGLIQQSAKALESAKFVYLMGADDVNVDKIPKDAFVVYQGHHGDKAVYRANVILPASAFTEKEGTYENTEGFTQQTVPAVPTVGDARDDWKIVRALSEVSGVKLPYNSIEGVRSRIKSVAPNLVHTDEREPAAFGPSLKPECKEAMSTTPFQTVVENFYMTNSITRASKIMAQCSAVLLKKPFV

81.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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