The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.

466 amino acids

MNNSTYINSSSENVIALESPYKTIEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGIFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGGRTVPDKDCYIQFFSNPAVTFGTAIAAFYLPVIIMTVLYWQISRASKSRIKKGKKEAAQNQDPVSPSLVQGKIVKPNNNNIPTSSDGLEHNKVQNGKTTGESVMENCVQGEEKDSSNDSTSVSVVPSNTKEDEAAKDASQISASQDHLKVENSKLTCIRIVTKSQKGDCCAPTNTTVEIVGTNGDEKQNSVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWTPYNVMVLINSFCASCIPGTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR

51.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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