Involved in the biosynthesis of the antifungal antibiotic pyrrolnitrin. Catalyzes the ring rearrangement and decarboxylation to convert 7-chloro-L-tryptophan (7-CLT) to monodechloroaminopyrrolnitrin (MDA). It can also use 7-chloro-D-tryptophan, but 7-chloro-L-tryptophan is the preferred natural enantiomer.

Belongs to the PrnB family.

361 amino acids

MERTLDRVGVFAATHAAVAACDPLQARALVLQLPGLNRNKDVPGIVGLLREFLPVRGLPCGWGFVEAAAAMRDIGFFLGSLKRHGHEPAEVVPGLEPVLLDLARATNLPPRETLLHVTVWNPTAADAQRSYTGLPDEAHLLESVRISMAALEAAIALTVELFDVSLRSPEFAQRCDELEAYLQKMVESIVYAYRFISPQVFYDELRPFYEPIRVGGQSYLGPGAVEMPLFVLEHVLWGSQSDDQTYREFKETYLPYVLPAYRAVYARFSGEPALIDRALDEARAVGTRDEHVRAGLTALERVFKVLLRFRAPHLKLAERAYEVGQSGPEIGSGGYAPSMLGELLTLTYAARSRVRAALDES

39.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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