Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (By similarity). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (By similarity).

Belongs to the AB hydrolase superfamily.

337 amino acids

MDIDVLNMFLVAGGTLLVPLLAFMTSFLLWPAALIRIYYWYWRRALGMQVKYSSYGNYKFCYTARGKPGNKPSVLMLHGFSAHKDMWLGMVKFLPKNLHLVCVDMPGHEGTSRSALDYYSICGQVKRIHQFVESIGLNKKPFHLVGTSMGGNVAGVYAAQHPTHISSLTLICPAGLMYPIESKFLKQLKVLEKSGDNQRIPLIPSTAGEMEDMLRLCSFVRFKIPQQVLQGLIDERIPHNEFYRKLFLALVDEKSRHSLHENMNKIMAPTQIIWGKQDQVLDVSGAEVLAGSLRGCQVEILENCGHSVVMERPRKSAKLMTDFLSSLQSTDNHKKHD

38.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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