Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.

Belongs to the methyl-coenzyme M reductase alpha subunit family.

555 amino acids

MEAEKRLFLKALKEKFEEDPKEKFTKFYTYGGWQQSARKQEFVSENEKIVAEKRGGIPMYNPDIGVPLGQRKLMPYKISNTDTYVEGDDLHFMNNAAIQQLWDDIRRTVIVGMDTAHMVLEKRLGVEVTPETINEYMHTINHSLPGGAAVVQEHMVEVHPSLAWDCYAKIFTGDDELADELDDRFVIDINKLFPEEQAEASKAAIGKKTYQVSRVPSLVGRVCDGGTISRWSAMQIGMSFITAYKLCAGEAAIADFSYAAKHADVIQMGNALLGRRARGPNELGGVRFGILSDVVQTTRVSDDPVEQSLEVVATGAALYDQIWLGSYMSGGVGFTQYATASYTDDILDDFSYYGYEYVEKKYGRCGTKATMDVVEDIASEVTLYALEQYDEYPALLEDHFGGSQRAAVAAAAAGISVCMATGNSNAGVNGWYLSQILHKEYHSRLGFYGYDLQDQCGASNSLAIRNDEASPLELRGPNYPNYAMNVGHQGEYAGIAQSAHSARGDAFATNALIKVAFADPSLVFDFSKPRKEIARGALREFEAAGERDPILPAKI

61.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.

Make mcrA using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)

Order Here