Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.

Belongs to the methyl-coenzyme M reductase alpha subunit family.

555 amino acids

MAEERKKLFVDALRKKFKEEPKERKTTFYTLGGWKQSERKKEFVEYGKKVAKERGIPAYNPDIGTPLGQRVLMPYQVSTTDTFVEGDDLHFVNNLAMQQFWDDIRRTVIVGLNHAHRILERSLGKEVTPETINHYLETVNHAMPGAAVVQEHMVETHPGLTADSYVKVFTGNDELADEIESCYLIDINKQFPEHQAEQLKKAIGHTIWQAVRIPTIVSRTCDGATTSRWSAMQIGMSMISAYKQAAGEAATADFAYAAKHAEVIHLGTFLPVRRARGENELGGVPFGFLADIVQSSRVHYEDPVRVALDVVASGAMLYDQIWLGSYMSGGVGFTQYATASYTDNILDDFTYYGKEYVEDKYGGLAEAPHDFDTILDVATEVTLYSLDQYEEYPTLMEDHFGGSQRAAIAAAASGCSTAFAAGNAQAGLSGWYLSQILHKECHARLGFYGYDLQDQCGAANTYSIRSDEGLPAELRGPNYPNYAMNVGHLGEYAGIVQAAHIARGDADSLNPLVKVAFADDNLPFDWTNPRGEFAKGALREFEPEGERDLIRPAGK

61.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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