Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

Belongs to the MGMT family.

174 amino acids

MILEVRKFQVKNKAVYIGTLSEDKIFGIIFSIDEPEVIRHRIPTLINFLEKRLNKKLEIKEGNSGFSDVVFKTLIGKISNEEAAEFIEVSYLTKFERKLYIYLVENVKRGEVITYGELAKILNTSSRAVGAAVKRNPYPIIVPCHRVIGRKNPYLYTPKPEYKKFLLEVEGWTS

20.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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