Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6 (By similarity).

590 amino acids

MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTATGNVEAKVLCFYRRRDISNTLIMLADKHAKEIEEESETTVEADLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSVKTLLADKGEIRVGPRYQADIPEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHSMDTLYRHGYDLSSAISVLVPLGGPVLCRDEMEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYKPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCATCWLYWKKYGGLKMPTQSEEEKLPPSPATEDPRVRSHMSRQAMQGMPVRNTGSPKSAVNTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVPINYAAIRAEYADRHADLSGSPLKSKSTRKPLACIIGYLEIHPSKKPNVIRSTPSLQTPTTKRMLATPNHTSLSILGKRNYSHHNGLDERLMK

67.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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