Photoreceptor implicated in non-image-forming responses to light. Photoisomerizes covalently bound all-trans retinal back to 11-cis retinal. Most likely coupled to the G(q) signaling cascade.

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

706 amino acids

MTEIPSFQPPINATEVEEENAVFPTALTEWFSEVGNQVGEVALKLLSGEGDGMEVTPTPGCTGNGSVCNGTDSGGVVWDIPPLAHYIVGTAVFCIGCCGMFGNAVVVYSFIKSKGLRTPANFFIINLALSDFLMNLTNMPIFAVNSAFQRWLLSDFACELYGFAGGLFGCLSINTLMAISMDRYLVITKPFLVMRIVTKQRVMFAILLLWIWSLVWALPPLFGWSAYVSEGFGTSCTFDYMTPKLSYHIFTYIIFFTMYFIPGGVMIYCYYNIFATVKSGDKQFGKAVKEMAHEDVKNKAQQERQRKNEIKTAKIAFIVISLFMSAWTPYAVVSALGTLGYQDLVTPYLQSIPAMFAKSSAVYSPIVYAITYPKFREAVKKHIPCLSGCLPASEEETKTKTRGQSSASASMSMTQTTAPVHDPQASVDSGSSVSVDDSSGVSRQDTMMVKVEVDKRMEKAGGGAADAAPQEGASVSTVSAQIEVRPSGKVTTKADVISTPQTAHGLSASPVPKVAELGSSATLESAAIPGKIPTPLPSQPIAAPIERHMAAMADEPPPKPRGVATTVNVRRTESGYDRSQDSQRKKVVGDTHRSRSFNTTKDHFASEQPAALIQPKELYSDDTTKKMARQSSEKHEYDNPAFDEGITEVDTDSENETEGSYDMLSVRFQAMAEEPPVETYRKASDLAINLGKASLMLSEAHDETVL

76.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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