Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Required for carbon dioxide and energy partitioning in leaves. May limit photorespiration during the dark phase (PubMed:20876337, PubMed:27208265). Its activity is essential to shuttle reductants out from the mitochondria to support the photorespiratory flux (PubMed:26889011). Can convert 2-oxoglutarate to (S)-2-hydroxyglutarate in vitro (PubMed:26203119).

Belongs to the LDH/MDH superfamily. MDH type 1 family.

341 amino acids

MFRSMLVRSSASAKQAVIRRSFSSGSVPERKVAILGAAGGIGQPLALLMKLNPLVSSLSLYDIANTPGVAADVGHINTRSEVVGYMGDDNLAKALEGADLVIIPAGVPRKPGMTRDDLFNINAGIVKNLCTAIAKYCPHALINMISNPVNSTVPIAAEIFKKAGMYDEKKLFGVTTLDVVRARTFYAGKANVPVAEVNVPVIGGHAGVTILPLFSQATPQANLSSDILTALTKRTQDGGTEVVEAKAGKGSATLSMAYAGALFADACLKGLNGVPDVIECSYVQSTITELPFFASKVRLGKNGVEEVLDLGPLSDFEKEGLEALKPELKSSIEKGVKFANQ

35.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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