Description
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
Family
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
Species
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Sequence
MRQPLLKLAAVTRRFPAGDKDVVVLNNVNLSIHAGEIVAIVGASGSGKSTLMNILGCLDHPSEGTYTVGGRDTHMLDSDELAQLRREHFGFVFQRYHLLPHVDAVANLEMPAIYAGTPRAERHARARELLARLGLADRAHHRPGQLSGGQQQRVSIARALMNGGQVILADEPTGALDTKSGQDVIRILHELNALGHTIVIVTHDKAVARHAKRIIEISDGEIVADRPNRHYAEALAEAGVDAAEAAEASEAAVGESPTRNRHDTPAPPAAVDTDPHVDTGTRTRRFAAGSGRFAEACRMAWIALVSHRLRTLLTMLGIIIGITSVVSIVAIGEGAKRYMLDEIGSIGTNTINIYPGTDWGDSRADAIQTLVPADVAALTEQPYVDSATPETSRTLLLRYRNVDVNALVSGVGDRFFQARGMRFALGVAFDEDAVRRQVQVAVIDQNTRRKLFGATRNPIGEVILVDNVPCVVIGVTADKKSAFGSVKSLNVWVPYTTASGRLFGQRYLDSITVRVRDGQPSAAAEKSLEKLMTQRHGRKDFFTYNMDSVVKTVEKTGQSLTLLLSLIAVISLVVGGIGVMNIMLVSVTERTREIGIRMAVGARQSDILQQFLVEAVLVCLLGGTIGIALSFGLGALFSMFVAQWKMVFSAGAIVTAFVCSTLTGVIFGFMPARNASRLDPIDALARD
Simulated SDS-PAGE
![Western blot of macB recombinant protein](/recombinant/macB-3.png)
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service