Description
Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
Family
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
Species
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Sequence
MSEPLIQLKGIERRYQSGEQEVTVLHPLDLTIEAGEMIAIVGASGSGKSTLMNLLGCLDRPSSGQYLFRGQDTATLDALSLARLRCHHFGFIFQRYHLLPHLNAAANVEIPAVYAGTSRAERQARSQALLTRLGLSDRSHHTPSQLSGGQQQRVSIARALANGGEVILADEPTGALDSQSGKEVMAILKELHAQGHTIILVTHDMEVASHADRIITLKDGRVQEDSGRKPAAVPVTPTAAPAGKEGVGHDWDRYREAARMALHAMLAHRMRTFLTMLGIIIGIAAVVSVVALGQGARAKVIDQINAMGTNTIDIFPGKDWGDEKAASIQTLNKRDLDALLGQPYLEGASPQIAAPGQLRYRNKTSSGSIVGVGNDFFRVKGMKLTNGRLFDERDIQNRAAVAVVDGKTIESLLGKQDPVGQVVLVGTLPVRIIGVVEEETGFGRSSQSVNVWLPYSAVMSRLISQNHFSQLTIRVKDGVQPALAEQAAIELLTQRHGVKDFFTFSSDSIIKSVEKTTATMTLLVSAIAVISLIVGGVGVMNIMLVSVVERTREIGIRIAVGARQSDILQQFLIEAVMVSLLGGMLGVGVSLFIGLLFSLFVESIQMHFSLFSILMAFGCSSLIGILFGYLPARNAARLDPVEALARE
Simulated SDS-PAGE
![Western blot of macB2 recombinant protein](/recombinant/macB2-10.png)
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service