Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).

Belongs to the MICOS complex subunit Mic60 family.

666 amino acids

MAMYLKSQAVLTLIPQRYHALARKSNAGRRCSLTPNSATASQFFQKAASSTSTKPPGPSDADVRSPASPSSRSSLRPESIPKPPQSPPVQGQTSPGSEVLPPDHESSTPPPPPPPPQGPKSSRLRKLLYLFLTAGLAYAGGVWYSLRSDNFYDFFTEYIPYGEEAVLYLEERDFRNRFPHVTKQINRRVTVPKDEGAQVTIPSGSGLSWKVAEEQQEATDMTKKGRRMGTAHANEPTKDIKVAEKAKEEVKSKSAAKKEDVAANIPIQEDLEPQPAKAEERNLDAPRQPAVPAATTIERLVQDKVDEPVVQDLVKVFNDVISVISADESASKFAGPIAKAKEELQRIGDRIVALKKDAQESAQEEIRNAHAAFDKSAAELIRRIDEVRTQDAAEFREEFESEREKIARSYQEKVNTELQRAHEVAEQRLRNELVEQAIELNRKFLSDVKTLVENEREGRLSKLAELTANVAELERLTAGWSDVVDINLKTQQLQVAVDAVRTTLENSDVPRPFVRELAAVKELASNDEVVAAAIASISPAAYQRGIPSAAQLVERFRRVASEVRKASLLPENAGITSHAASLVLSKVMLKKQGLPTGDDVESILTRTENFLEEGNFDEAAREMNSLQGWAKLLSKDWLADVRQVLEVKQALEIIETEARLRCLQVE

73.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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