Probable component of a SCF (SKP1-CULLIN-F-box protein) E3 ubiquitin-protein ligase complex and may function through the ubiquitin-mediated protein degradation or signaling pathway. Required for male meiotic prophase I progression. Required for telomere bouquet formation, homologous chromosome pairing and for the formation of the synaptonemal complex (SC), which stabilizes initial chromosomal axial associations and promotes crossover formation. Involved in meiotic DNA double-strand break (DSB) end-processing and repair, and is important in the recruitment of DSB repair proteins to the DSB sites.

Belongs to the F-box protein family. FBX subfamily.

475 amino acids

MRRERDATQIPENPMEGIPQTAAAAAAAAAAEASEPPRKRARVDGGGGGAGEEEEDRLSDLPDCLLEDILAHLGSRQAVQTSVLSRRWRNLWRGVRVVVIDVGSFRLPGADGDPPRFRLDRIEDFADGVLSPSLHPGAARELDALRMRLDEDAVTTNFQRWIRRALWRRPATVDLYYLPRRSFSWPPAVPLTPVTAVSRLKTLRIFGLRPTVVFGADEFPALEDLHIERCSYAHGTIASPTLKRLALVSPINGCFVREQRLTAPGLTSLRLVLPYSREEGVRVITDAPLTSLVDASITIVDTDPGDPRNRRVNQFKVDFLVAISNLLGRLTSVRNLDLTGLNATALLDNKSQEFPMFPYLTTLLLNECDIGYKYHVLRSILQNAPNLEQLRLHNCKFVGKSRRKAGQTQSKEKTSKCSSSTLSSACSSLKSVEIKHPRGEPSHDLLHEFLKEIPHNQWRKRSIDEETISIELNRK

53.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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