Plays a novel and significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of rab-3 and cab-1 to the GTP-bound active forms. Regulator of presynaptic activity that interacts with rab-3 to regulate synaptic vesicle release (PubMed:9136770, PubMed:10970871). Is also a regulator of the cab-1 synaptic transmission pathway (PubMed:10970871). Probably by converting rab-3 to its GTP-bound active form, plays a role in the recruitment of endophilin unc-57 to synaptic vesicles (PubMed:21029864). Probably by activating rab-3 and thus regulating the trafficking of dense-core vesicles, plays a role in AVG neuron-mediated formation of the right axon tract of the ventral nerve cord (PubMed:27116976). Regulates anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP) (PubMed:18852466). Probably by regulating DMP, required for fatty acid uptake by intestinal cells (PubMed:25849533).

Belongs to the MADD family.

1409 amino acids

MNDKEKEICPRLIDFLVVVGKRNRTRGASQSSPDATTDTTVTYPEILRRYPTDDHKDFILPTDVTVFCQPEGCTTTSARLRKNARNDPQFFVFMLTEKDSAKVRYGICLNFYQSFDRRSTPKDEIKKVPDDAHHKKRDSHVSLTSLCFISHHPFVSIFHQVLLLLKRIIDSSNHRAAQRTGLKDVVWAILTGHYNEPIVPEVMKEIKEIETWILMLLSSPVPVPGKTKVQIEVMPMDLSQVFEFALPDHTRFTLIDFPLHIPFEILGIDMALRVLTAAMLEFKIVIQSRNYNAVSMCILSIVALLYPLEYMFPVIPLLPAYMPSAEQLLLAPTPFLIGVPSSFFHHRKIRELPSDVILVDLDTNCLQVPDDLYIPDLPEPDATHLKERLKNAINKMTTMTVDNETSVTDADFGIDIDSVDVACRVAMVQFFNSANVFGNFSEHTRTLRLYPRPVVSLQTDSFLRSRPQCTQLITDLCRTQAVEYFAECCLCPKNETFVRVQAGIESAEQVGDKPKWFSESLMPVHFMVYPNNSTLDSAIRVYNAEIDNDDYEDDSATSTENSNSIDDLVFDENQVTDAGGEVTKPLAEVNYIYKEPMTLELPQSESVVSIDSSLSSGRSSPDSSLSTSAVDSEADFARLADNLALKSNSQGAFSFDHGSDSEYESTPVSQRRKTIHNPGSDASDTPTSRGSIKSGLRMKGLTTLTDSGEKVLGPSLMNAINGYAEKSQSVFSQVINKTAPKAQALKERTMKPLANRIEQSQHIVRSKTQPNPTSQQTANQQSKNQQTVKEFCDQALVGQSVGMFSAPKLKRLMEDESLRELVCSKLNLGLEVKLSEDEYVKEVQLTKGQFKAYVKILKACLEGIEVSFNTPGCCGFASVFHVLEIAHTHYWAMGGGEVITPSSSAPSTMTTPSEHSNDILKESRPKLPASTIDLRTPTKPLGQNVTPTSTNNHEIAQSTRSPALPPPVPPREAPPIPKRNPPPLGAPPKVPEGARAPPPLPPRPKVKTTAVDETPQNLVPNNQPAQPSSPSFLADADEQTKPLLKPAPPTTLPVGKQEPCKVLPTPNEPVRHYIYQELILAVQHQIWQNLQFWENAFVDLVAQEREIVGMDQEPSEMIDRYSALNDSEKKRLELEEDRLLSTLLHNMTAYMIMCGTGQKALQQKVRRLLGKAHIGLVCSKEINKLLDELPSTQGNFIPLKPLGSRLVQKQSFTVCPGQSSDGQMMFMEVCDDAVVLRSITGAATERWWYERLVNITYSPKTKILCLWRRHDDKVHMHKFHTKKCRELYQCMKAAMERAAARGKVNVEGRALGGEFPVHDTETNQGGLLQVRCDGVAVIFAHNQIFIGLSNIKKCNTFGGNVFLLEEFDRKKGEIIQRRYFSQMADQICYAVLCVFSLAAAGHKKEEHSK

157.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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