Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (By similarity). Required for establishment of the hematopoietic and endothelial lineages (PubMed:18388326).

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

388 amino acids

MVSPRGVCFLLFLLLGSVFGSVFMLGPLLPLMLLSPSRYRWITDRIVATWLTLPVALLELVLGVKVVVTGDGFIPGERSVIIMNHRTRLDWMFLWCCLLRYSYLRQEKICLKAALKSVPGFGWAMQVASFIFIQRRWEDDRTHMSNMLQYFCRIREPVQLLLFPEGTDLTENTRARSDEFAEKNGLQKYEYVLHPRTTGFTFIVDTLRGGDNLDAVHDITVAYPQNIPQTERHLLAGVFPREIHFHVQRFTVASVPAGAAGLQAWCQERWREKERRLQRFYETVPRRFDAPAVGVCVREPCCQSGQCVCVPRCKSEGRVRIILVASLLYWSVFITAACASLCLCPPAQFYFLFMVVFFLCQQRFTGGLELMELACHRYWSRRSADKQE

44.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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