Protein expression services for kdm2b | Lysine-specific demethylase 2B
Description
Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation.
Family
Belongs to the JHDM1 histone demethylase family.
Species
Xenopus laevis
Length
1259 amino acids
Sequence
MEAKKDSARRLRSIDRTRYAEHEDLSDVEDMVSIRGFSLEQKVSCNAYRGNFVRYMEGKDFTYEYVQREALQTPLLFSTKEGLGIKMPEQDFTVRDVKLLVGSRRVVDVMDVNTQKSIDMSMSQFVRYYETPEMEREKLYNVISLEFSHTKLERVVKRPTVVDAVDWVDNMWPRHLKEQQKESTNVIAEMKYPKVKKYCLMSVKGCYTDFHIDFGGTSVWYHVFRGGKVFWLIPPTGHNLQLYEEWLLSGKQTDIFLGDRSEGCQRIELKQGQTFFIPSGWIHAVYTPADSLVFGGNILHSFNIPMQLRVFEIEDRTRVNAKFRYPFYYEMCWYVLERYVCTLTKRSHLIKEYQRESMITDRKPSLDSHSSDSWLEMEEESCDIHIKEEKGNLVEKPSKQSGDESSTTNSTHSNGKDAAEKKQKATLMQQLKRTLSNDSDESSKSIVHSDFPKTPTGSPATDMPCKLTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEDMKTVLKEHADDDNNLAISGVPVVMWPKKPSKNRAVGRPKGKIASSPAVKLSANRTSAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDCVEGQEAKFNVMLMECSICNEIIHPGCLKTKESDGVVNDELPNCWECPKCNHAGKTGKVYKQKRGPGFKYASNLPGSLLKEQKVNRDNKELTEIVKKKVEREETPKQIPEEQPKKKPTEGIIKKKPEDGHVRKKRKFEKPPDPSVRKRLKLVKEEKLLRKKRRSWKTPDERAMMAKTLRRIKQEPDDDLTEAAPKAKESDQSRSSSPTAGPSTEGSEPKEKKKIRRKRRVSNKELSKELSKELNQEIQKTESSLASENHHPIKSEPESDNEESKKCISTNGERMHNFSKGLNGTPKELRHELFPSLKTTPRANNRPPPSLSPPKCMQMERHVIRPPPISPPPDSLPLANGAAHVMQREVWMAIFSYLSHRDLCICMRICRTWNRWCCDKRLWTQIDLNRCKSITPLMLSGIIRRQPASLDLSWTNISKKQLSWLINRLPALRDLNLSGCSWIAVSALCSSCCPLLRTLNVQWVEGLKDAQMRDLLSPPTDNRPGQIDNRSKLRNITELRLAGLDITDASLRLMIRHMPLLAKLDLSYCNHVTDQSINLLTAVGTSTRDTLLEMNLSDCNNVTDQCLTFFKRCGNICLIDLRFCKQVSKESCEQFIAEMSVIVQFGQTEEKLLQKVS
Mass
144.1 kDa
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service
Make kdm2b using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)
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