Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis (By similarity). May play a role in the regulation of circadian gene expression (By similarity).

Belongs to the JHDM1 histone demethylase family.

1146 amino acids

MEEEQLRYSRRLRHTLRRRYEDDGISDDEIEGKRTFDLEEKLRSSKYNSNFITYMEGKDFNMKFIQEGGLRDPIIFTKSEGLGIKMPDPNFSVNDVKMFVGSRRVVDVMDVGTQKGIEMTMAQWAKYYETPEEEREKLYNVISLEFSHTKLENLVQRPTTVDQIDWVDNIWPRHLKDRQTESTNVIQEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHILRGGKVFWLIPPTDQNLELYENWLLSGKQGDVFLGDRVTECQRIELKQGYTFVIPSGWIHAVYTPQDTLVFGGNFLHSFNIPMQLRIYSIEDRTRVPTKFRYPFYYEMCWYVLERYVYCMMRRSHLTKEFQRESLSIDLELNGRQRPDTPSSSSSSSSSGLSSSSDNDDSSDQDWEEEEGLRKRERDRCRVERELQRKRNRDRQQRDQERDRHGRTERIIIHTLPASLRPLTPPPSLPLPTPDSPPSTSPFLTWFEVEGLRCLVLKLESLPPLKKCLPDGIHDPEALIFDIKRLLEDHAHDPPELALTGVPIIQWPKRSQYKVHLRPKIQFTKPHTMRPASRHSTAPPRTSGTPSGTTASSGARRRRVRCRKCQACVQRECGTCHYCKDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCALCGEVDQTNDTQDFERKLMECSVCNEIVHPGCLEMDGEGLLSDELPNYWECPKCYEGQKHTVEANHDRILLHSKRKAADNYESSHYYPAKVLRPPLGQSPPSPPLLLLPPSPSSAPPTPPSAQTQVPLASREERAKRRQLAREKENHPTGCDQSEGDRLRLRGPYLTVTLQRPPKELSSTSIVPKLQAITPNPRQPIRAAPLHQDEEREEEEEEEEEEEETENVMLGQRKDSTSMQKDVWLSVFHYLTHEELCICMRVCKAWYKWGCDKRLWSRIDVSRCKSLVPQALSGIIKRQPIYLDLSWTNVSKKQLIWLINRLPGLKDLILAGCTWSAVSALASCSCPLLRTLDLRWTVGIKDTQIRDLLTPASDKSGHDSRSKLRLLTDLRLSGLDISDVTLRLIIRHCPLLSKLDLSHCPLLSDQSVNLLTAVGSSTRGTLTHIHLAGCKGVTDESLLYLRRATNLSLIDLHGCKQVTRGACEEFISDLSVSTLYCLSDDKLIQRIS

131.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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