Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.

Belongs to the LDLR family.

single

837 amino acids

LLAAAAGAAAGDKCGRNEFQCRNGKCISYKWVCDGSSECQDGSDEWEQTCMSLTCKSDDFSCGGRLNRCIPGHWKCDGQQDCEDGSDELGCAPKTCSQDEFRCAEGACISRLFACDGEPDCPDGSDEASCAPSTCGPAHFRCNSSSCVPALWACDGEPDCDDGSDEWPARCGARPSPQPGRGPCSRHEFHCGSGECVHASWRCDGDADCRDGSDERDCAAATCRPDEFQCSDGTCIHGSRQCDQQQDCGDMSDEVGCVNVTLCEGPDKFKCHSGECISLDKVCNSARDCQDWSDEPIKECATNECMRGNGGCSHTCFDLRIGHECHCPKGYRLVDQRRCEDINECEDPDICSQLCVNLAGSYKCECRAGFQLDPHSQACKAVDSIAYLFFTNRHEVRKMTLDRSEYTSLIANLKNVVALDAEVASNRIYWSDLSQRKIYSAQIDGAHGFPAYDTVISSDLQAPDGLAVDWIHGHIYWTDSVLGTVSVADTRGFRRKTLFRQEGSKPRAIVVDPAHGFMYWTDWGVPAKIEKGGLNGVDVYSLVTEDIQWPNGITLDLSSGRLYWVDSKLHSISSIDVNGGNRKTVLEDEQRLAHPFSLAIFEDKVFWTDVINEAIFSANRLTGSDVHLVAENLLSPEDIVLFHNLTQPRGVNWCEKTALPNGGCQYLCLPAPQINSHSPKFTCACPDGTLLAADMRSCRTEADVILSTQRASTAARPQLTGSPAGTTQEPLTEPTLSTLETATTSQQALHNADGRGSEGTPRSVGALSVVLPIALLGLLCLGALVLWKNWRLRSVHSINFDNPVYQKTTEDEVHICRSQDGYTYPSRQMVSLEDDVA

91.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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