L-ornithine N(5)-monooxygenase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence (PubMed:20507510). Gibberella zeae produces extracellular coprogen-type siderophores as well as the intracellular siderophore ferricrocin (PubMed:17056706). The role of extracellular siderophores is to supply iron to the fungus during plant infection, and the intracellular ferricrocin is required for intracellular iron distribution and storage with a crucial role in ascus and ascospore development (PubMed:17056706, PubMed:17043871, PubMed:17601875). SID1 catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores (PubMed:20507510). The assembly of extracellular coprogen-type siderophores is performed by the nonribosomal peptide synthetase (NRPS) NPS6 whereas the intracellular siderophore ferricrocin is assembled by NPS2 (PubMed:17056706, PubMed:17043871, PubMed:17601875).

Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

536 amino acids

MSPHSEISFSGSDAAVSNGTSNGINGHSNGTNGFSNGHMNGHSNGNDAPTAVRHGPRVHKERSRHLETAPVDSEFDLICAGFGPASLAVAVAMHDAIAEGRNLRPDGTAPKVLFLEKQPKFAWHAGMLLPGAKMQISFIKDMATLRNPRSEFTFLNYLHSQGRLVDFTNLGTFLPARTEYEDYLRWCSSWFDHVVNYNNEVLSISPENKEAGAVKTFTVQARNGKTGQIQSFRSRHVLVAAGGQPSLPKSLPAKHPRVLHSSQFANYAPQILTKQNAPYRVAVIGAGQSAAEIFNNVQNLYPNSKTYLIMRQEFLRPSDDSPFVNSIFNPEYIDNLWPRSVKARETLLTEARATNYGVVRLELIEHLFEKMYDQKREISDDETQWPHRILSGREIASVDTKGDALEIKVQRVNDGPLDGFVDQETFDVDLIIAATGYKRSAHIDMLKDAWTMLPKTVSGRNESPKGANGWNVETQDGERKLAVARDYRVKFSPGTVADDSGVWLQGCCEGTHGLSDTLLSVLSTRSGEIVQSIFKQ

59.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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