ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

956 amino acids

MLSINNKLKNLKLSTVKNLYNKSSSISIILVNNNNNNNNNNNNNNNNNNNNNNNNNNFISLSTTNLFNQKLCIESYKKVNYCKKKGGGNKNNDDNDNEKNEKNEKKVKNEKKEKNEKNDGNEKVEIVEDNDLIVPLSKELLQFDKPSNKRKDWPLNSEVVIYPSNSVNFIGTTGPINLGFQFITRLVPNASGKTFLGFFLCKDAYRNNNNQIGRTIDSIHNVGVLAQVTLSPSGIYHFETIKRIRIKEVQNGQFPFIASIEPLSNDERELKDPRIAELMTKINVLSLEYRKLYPDVYTINSVDFENQIEVIDNPDYYLAAVINYYGLNYPDECQKILETQSVVKRLEMLYHMILNEQPLLALQQKIAKDLDDKTTAYKNKLLLTEQLKKLKALLGNETDEKEKTIEKYQNKLSELTLISESSKKVIQDEIYKISTIDPSSSEYSALKNYLEWLTNLPWGIYSADYFDLKHSKMVLDSDHYGLEDIKQRILEFISVGHIKGTVQGKILCFIGPPGTGKTSIAKSIAKALKKEFFRFSVGGLFDESEIKGHRRTYVGSMPGKIIQALKITQTSNPVILIDEIDKIGKRNHGDPSSALLEVLDPEQNVSFVDHYLDTPYDLSKVLFICTANSGQDIPAALSDRMEIIRLPGYVEEEQIEIVKNFIIPKTFIDCGIKLDQLSISDDVIKQIVKFYSREVGIRELEKLIEKIMRKTALKLVNGTAERVDLTLDNLEQYLGIPSYTSDRYYDVTPIGVVNGLAYTKKGGATLYIESTSEEIQKPLSSLPPSQQQQNQLEPSIKTTGNLGDVMSESSTIAYTFAKNFLYELDPNNTFFSNHNIHLHSPQGNIPKDGPSAGVTMVTSLLSLALNEPVQNNLGMTGEVTITGKVITIGGVKEKTIAAKRSGLTSVIFPINNRINFEELPTYIKNDIDVTYANDYKDVFEVAFPNKKYLLNNLKTF

108 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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