ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.

Belongs to the peptidase S16 family.

1004 amino acids

MGLFGKDRGERIAEFPCYLLETGTHLVPLPGILYNLVIERTYGERILGQFRGIGEAVDGALTGAGEAAEVPGRVAEVMKAFQERYDSGDKTQAVYICLVTEAAAGRHIGCIARLTGARAEGGELSVLLRGLVRAVVGQPVPSRRNEMWNGSVTVLDDAQRVATWGARQLDFARQGVFGAFEELDAGIGTFTARFKSSQKRGADGAAHLLTLSPLANTLFFHFSRSSFERSWKILRTMMHGFRDAKKDIRTAMDMLSVADLTVGLLPTTTAQRLEFLQAEDPAARIKTFVRHMQQLLEVFGSLYRATEYVHDRFETHGPIAKSQLIANQLRSLRFYIDDIKRNKPESGPGGRSRRLLPRPASGNSAAAGEEDDSEDSELVAIKRYVDEIEVKGVHADGVKMLKKDYRSLSKMHVQSTEYQMLRNYFDFIMGIPFGIYVSTPEIDLVASSRKLDNDHYGLVQVKKRLLEYLCVLKLSANSPGVTADAGAIEDGSATKRAVVYENKAQEQRKTKVPFLLLVGPPGVGKTSVAKSVADVLGRRFQRISLGGIHNEAEIRGHRRTYVGAMAGMIVNALCKAGCMNPLILLDEIDKVLSVPAGAGASRLNGDPGAALLEVLDPEQNHTFTDHYVGFPVDLSQVLFFCTANDLSGMSEPLVDRMEVIHIEGYTYEEKIAIGRHFLLPKQIRLNSFDMTGINLSLTDDAWRTVVVDYTREAGVRNLDRQLGAIVRGKIVEYVENNMSGSGDDVVTQKNLPKFLGLPPHSLREEVTQTTSFAEKYGVVHGLSYNSDGTGGVLVFEVIRSGDSRDKRLTVQTTGNLGTVLSESVSIATSLVKSLLARHVVHSSADDTSVAEFFRSECHLHVPFGAVPKDGPSAGAAISLALLSLALKRPVDPALCVTGEITLRGKILPVGGVKEKLLAAQLQGMGLALVPRGNRNDLVELAEDNAETQQRLLADPALPELATLQHKLGMAVHYCSDFRDLVLHAWPTADNLWHACEDSSVRPQL

109.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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