3-O-methyltransferase involved in the synthesis of L-oleandrose, a sugar attached to oleandomycin, a macrolide antibiotic. Acts on monoglycosylated macrolactones and mediates the conversion of L-olivosyl-erythronolide B into its 3-O-methylated derivative, L-oleandrosyl-erythronolide B. Also able to methylate other monoglycosylated derivatives, such as L-rhamnosyl- and L-mycarosyl-erythronolide B.

Belongs to the methyltransferase OleY/MycE family.

386 amino acids

MSYDDHAVLEAILRCAGGDERFLLNTVEEWGAAEITAALVDELLFRCEIPQVGGEAFIGLDVLHGADRISHVLQVTDGKPVTSAEPAGQELGGRTWSSRSATLLRELFGPPSGRTAGGFGVSFLPDLRGPRTMEGAALAARATNVVLHATTNETPPLDRLALRYESDKWGGVHWFTGHYDRHLRAVRDQAVRILEIGIGGYDDLLPSGASLKMWKRYFPRGLVFGVDIFDSRRATSRVSRRSAARQDDPEFMRRVAEEHGPFDVIIDDGSHINAHMRTSFSVMFPHLRNGGFYVIEDTFTSYWPGYGGPSGARCPSGTTALEMVKGLIDSVHYEERPDGAATADYIARNLVGLHAYQTTSSSSRRAINKEGGIPHTVPREPFWNDN

42.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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