Catalyzes the alpha,gamma-elimination of L-methionine to produce methanethiol, 2-oxobutanoate and ammonia, and that of L-homocysteine (By similarity). Can also use L-cysteine as substrate, catalyzing its alpha,beta-elimination; this activity seems to only minimally contribute to the production of hydrogen sulfide (H2S) by F.nucleatum in the oral cavity, which is toxic for a large variety of cells in periodontal regions (PubMed:21798982).

Belongs to the trans-sulfuration enzymes family. L-methionine gamma-lyase subfamily.

395 amino acids

MEMKKSGLGTTAIHAGTLKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTRFGVEVTFVDTSNLEEVKNAMKKNTRVVYLETPANPNLKIVDLEALSKIAHTNPNTLVIVDNTFATPYMQKPLKLGVDIVVHSATKYLNGHGDVIAGLVVTRQELADQIRFVGLKDMTGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIVDFLNKHPKVEKVYYPGLETHPGYEIAKKQMKDFGAMISFELKGGFEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREVAGITDGLVRLSVGLENVEDIIADLEQGLEKI

43.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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