Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.

Belongs to the radical SAM superfamily. Lipoyl synthase family.

378 amino acids

MLTSIRHNYRLSAIITPTTAAQADTLNAGPSFGDFVAPDAPLSPAEAYEIKTVQVGPEGRKKTITRLPEWLKTPIPSNANYKKIKKDLRGLNLHTVCEEAKCPNISDCWGGSDKSAATATIMLGGDTCTRGCRFCSVKTSKAPPPLDPHEPENTAEALSRWGLGYVVLTIVDRDDLADGGARHAMETIMKIKQKAPSMLVEALVGDYAGDAEMVKLVANSGLDVFAHNVETTEALTPYVRDRRANFKQSLNVLRIAKETKPELITKTSIMLGLGETEDELWKALKDLRANDVDVVTFGQYMRPTKKHMAVHEYVTPDVFEMWRQRALDMGFLYCASGPLVRSSYKAGEAFIENVIKKRRMGRGGQVGGAQIAEMEKSA

41.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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