Probably represses a number of genes involved in the response to DNA damage (SOS response), including itself, recA, uvrA, ruvAB and ssb (PubMed:15528664). The probable consensus LexA box is 5'-TGCAC-N4-GTGCA-3' (PubMed:15528664). In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (Probable).

Belongs to the peptidase S24 family.

217 amino acids

MENTNEKRKEMTARQEEIYEYIKKYSKENHMPPTVREIGNHFDISSTNGVRSILAALIKKGYINRSPRLSRGIEILSDDKESSKEVASNTIEIPIVGRVAAGTPILAVQNLEGTVTIDRDFLACRSDVFALRVKGDSMINAGIFDGDLIFARQQKTADLGEIVVAQIDNEATVKYYHPSADHVELRPANPKYKPIIVNNRKDFSIAGRVIGVMRKVN

24.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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