Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro.

415 amino acids

MEKLQDQYSFLCSENIRKTNPLILNILQKLDEEIEKRPKEKITVNIAGNSRLDSGQRITSEDFWLLSKALRNHPCIGGVDVRYNLIGDVGAYYAAKLLQKQPNITYLNLMFNDIGPEGGELIAKALQKNKTLKYLRMTGNKIENTGGMLFAAMLQMNSSLEKLDLGDCDLGLQSVIAFSTVLTQNKAIKGINLNRPILYGEQEESTVHIGHMSKQNHVLVELHMCKHGMKNYGIQQLCNALHSNSTLRYLDVSCNKITRDGMVFLADVLKSNSTLEVLDLSFNRIENAGAKYLSETLTSHNRSLKALSVVSNKIEGEGLVALSQSMNTNLVLSNIYIWGNKFDEDTCVAYSNLIESGRLKPENTDVEPYVVDEHIYLSEVSNGLKRHYYWTPTYGECYVPSSSAGFALVPVGERL

46.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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