Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription (By similarity).

847 amino acids

MDGRAEMEVVRTTKGNAAGEVSVHVVTTESTVQSTHLPTTAFIFPSQANATTINLPTSTLEIQRFPREPPRNTGAERPEKGVGSEPITATVIPQISGVQTCNTVRVLEWKDGVATLPGSNLRFRINEYGTLKVVSADKMPPAEAVKEGHAKKDGDSDVAPTSRDNTIVAQDVPEQSKLPTADSICHCDTCGRRHVSDGAREGRGFCSEHCHQQFKERSVIVENSASSTSATEILKPVKKRKRKDYQSPSEEDYESEQMEEKQEEMKNSVGDSAISNPEAHAWSQHSTEGPGASEEKKEGWSWASYLEEQKAVAAPLDLFQDYQVASQHKNGFKVGMKLEGIDPQHPSMYFILTVAEVCGYRMRLHFDGYSECHDFWLNADSPDIHPAGWFEETGHKLQPPKGYKEEEFSWTNYLKITKAQAAPKHLFVIRNTHEAPPGFEVGMKLEAVDRMNPSLICVATVTDVVDDRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQEHGKPLTPPQDYPDPDNFIWEKYLKETGASAVPAWAFKVRPPHGFLVNMKLEAVDRRTPSFIRVASVEDVEDHRIKIHFDGWSHVYDFWIDADHPDIHPIGWCSKTGHPLQPPLRPKEPASSAHSGCPTLGCKNIPHTKSSKYSFHHRKCPTPGCDGSGHVTGRFTAHYCLSGCPLAEKNQGKLKADLSDTEASTRKRNLIGFPQRKKSRHHGSFRGRPPKYRKIQQEDFQTISSDNMHQSLFMSALSAHPDRSLSLCWEQHCKLLPGVAGITATTVAKWTIDEVFSFVQTLTGCEDQAKLFKDEMIDGEAFLLLTQADIVKIMSVKLGPALKIYNAILMFKNADDTLK

94.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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