Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity).

Belongs to the lariat debranching enzyme family.

534 amino acids

MKIAVEGCCHGELDKIYETIQFLEKKENTKVDLLLCCGDFQAVRNEGDMKCMAVPQKYRQMQTFYKYYSGEKLAPILTIFIGGNHEASNYLQELPYGGWVAPNIYYVGYAGVVKYRGVRIGGISGIFKSHDYRKGHFERPPYSKDTVRSAYHVRNIEVFRLKQLKEPMDIFMSHDWPRSIYHYGNKKQLLKKKDFFRQEVENNTLGSPAASELLLHIQPSYWFSAHLHVKFAAFMQHQTNVEGEIPKATKFLALDKCLPHREFLQIVDVEHDPGKPDCLEYDLEWLAVLKATKDLLNITSKTWNMPENNGLHSRWDFSASEKTKREILDDLGHDIKIPCNFCMTTACYDPNNPQYKRVATHIVNPQTTEFCARLGLVDLNAKIRQHEEEGDIDITEDNEADSIGSAEDPGEYSTDTSLLSTSINPDEIALEDDDDQEDEGMAEKLGEPSPDYTPDLSINFSNIRVLPDSMAVSSDDATDSTNDELDRSESSQTEGEGKQSNRPLKRMSNENGSGGVKIKRRNQAIYQAKDDEDE

60.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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