Required for specification of the AIA and AIY interneurons and the NSM neurons. Positively regulates the expression of a number of genes including ceh-23, kal-1, hen-1, ser-2, unc-17 and sra-11 in AIY interneurons and cat-4, flp-4, bas-1, ptps-1 and mgl-1 in NSM neurons. Also acts in an autoregulatory feedback loop to maintain its own expression. Plays a role in the thermotactic response, olfactory imprinting, regulation of longevity, control of dauer formation and axon outgrowth and pathfinding. Not required for normal chemosensory behavior.

409 amino acids

MYFQSLSADPLDSVNTTTDFNQLAQLLLMLTNSSSKETIATHVVTNSVPSAFQFDWSSHFKEEYDLVEKLNSPQYTNLTSISPSSSTDSNNLILRQIQIPKIEPALLNQCCLCTFAIVDKEISVVDGKYYHNNCLRCQMCDIPFEYSDKCYVRDGVFLCRADHAKRYQKCCRKCEIPLNREDMVMKAKEMIFHHACFVCFICGIKLNPGDYYTMSPQGHLYCHAHYNAVRSTVLCEEAAVATVPAVVAPPPPPPTTTTAPPPAAPEQPPREASTEAEASTDEDGNGSGSQRSKRMRTSFKHHQLRAMKTYFALNHNPDAKDLKQLAAKTNLTKRVLQVWFQNARAKYRRELHDGGRSSSPLCVSAPLASMDMNPPLSSSSSGHSTDGYQLNTPPLSSEIYSPNSNYTHL

45.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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