Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis (By similarity).

493 amino acids

MSAEEMVQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVGPEVQQLRGLSAPGLRLVLDFINAGGAREGWGLSEDELAEASVLSEMVEAASFLQVTALLRLLLSHVRLGNCLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFPLLLSPPQAPGDCSLKQRLREARMRGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEETTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPITNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSADLWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVTLSTSLEHRVFLKYNIFADSWEAFRRFPAFGHNLLISSLYLPNKAET

55.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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